Pletal 100 Mg Tablets

Pletal to store Pletal 6. The inhibition is effective against a range pletal aggregants including shear stress, arachidonic acid, pletal, collagen, ADP and adrenaline ; in man the inhibition lasts for up to 12 hours, and on cessation of administration of cilostazol recovery of aggregation occurred within hours, without rebound hyperaggregability. Pletal tablets should be taken 30 minutes before breakfast and the evening meal. Your medicine is supplied in packs of 14, 20, 28, 30, 50, 56, 98,or tablets or hospital packs with 70 5x14 tablets. Other potential interactions Caution is needed when co-administering cilostazol with any other agent which has the potential to reduce blood pressure due to the possibility that there may be an additive hypotensive effect with a reflex tachycardia. This will allow quick identification of new safety information. The pletal of intraocular bleeding may be higher in patients with diabetes. Caution should be exercised when prescribing cilostazol for patients with atrial or ventricular ectopy and patients with atrial fibrillation or flutter. This will allow quick identification of new safety information. In a single-dose clinical study, no inhibition of the metabolism of warfarin or an effect on the coagulation parameters PT, aPTT, bleeding time was observed. Possible side effects 5. Cilostazol is only recommended for patients whose symptoms pletal not improved sufficiently after making life-style modifications such as stopping smoking and increasing exercise and after other appropriate interventions. Pletal other ingredients are maize starch, microcrystalline cellulose, carmellose calcium, pletal and magnesium stearate. Do not pass it on to others. Otsuka Pharmaceuticals UK Ltd, pletal. The dehydro metabolite and 4'-trans-hydroxy metabolite are

It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. Cilostazol pletal, white, round. At lower dose levels, retardations of ossification were observed. Cytochrome P enzyme inducers. You may need to read it again. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. If you have any further questions, please ask your doctor pletap your pharmacist. Very common Common Uncommon Rare Very rare. Pletal is not suitable for children. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis, pletal. As with other positive inotropic and vasodilator agents, cilostazol produced cardiovascular lesions in dogs. After 12 weeks, as compared to placebo, Pletal mg b. Before you take Pletal 3. Administration of a single dose of mg cilostazol with ml grapefruit juice an inhibitor of intestinal CYP3A4 did not have a notable effect on the pharmacokinetics of cilostazol. Cilostazol 50 mg-AND, white, round. If you get any side effects, talk to your doctor or pharmacist. Do not use Pletal after the expiry date pletal is stated on the carton plletal blister after "EXP".

Explore Everyday Health

All healthy subjects in the study had a prolongation of bleeding time on clopidogrel alone and concomitant administration with cilostazol did not result in a significant additional effect on bleeding time. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. Investigation of QTc in dogs pleatl monkeys showed no prolongation after administration of cilostazol or its metabolites. However, caution is advised in patients receiving both cilostazol and any anticoagulant agent, and frequent monitoring is required to reduce the possibility of pletal. The following side effects have been reported during the use of Pletal but it is not known how frequently they may occur:. There are two major metabolites, pleetal dehydro-cilostazol and a 4'-trans-hydroxy cilostazol, both of which have similar apparent half-lives. Marketing authorisation number s 9. You should tell your ppetal as soon as possible: The usual dose is two 50 mg tablets twice a day morning and evening. This medicine has been prescribed for you. If your blood pressure falls too low, this could cause a fast heartbeat. Do not use Pletal after the expiry date which pletal stated on the carton and blister after "EXP". Cilostazol 50 mg-TEV, white, rectangular. In a clinical study in healthy subjects, cilostazol given mg b. No effect on fertility was observed in rats or in non-human primates. Every effort has pletal made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. This site uses cookies. The information contained herein is not pletal to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. During treatment with Pletal make sure that If you need to have surgery including having teeth removed, tell your doctor or dentist that you are taking Pletal, pletal. This medicinal product is subject to additional monitoring. Based on these data, no dose adjustment is necessary. Long-term treatment with cilostazol did not raise safety concerns. The excretion of cilostazol in human milk is unknown. Fertility Cilostazol reversibly impaired fertility of female mice but not in other pletal species see section 5. However, the AUC for cilostazol and its plftal increase approximately proportionately with dose.

There are no adequate data in the use of cilostazol in pregnant women. Antithrombotic agents, platelet aggregation inhibitor excl. Oral Anticoagulants like warfarin In a single-dose clinical study, no inhibition of the metabolism of warfarin or an effect on the coagulation parameters PT, aPTT, bleeding time was observed. Since cilostazol is extensively metabolised by hepatic enzymes, it is contraindicated in patients with moderate or severe hepatic impairment. No effect on fertility was observed in rats or in non-human primates. Cilostazol is pletal recommended for patients whose symptoms have pletal improved pletal after making life-style modifications such as stopping smoking and increasing exercise and after other appropriate interventions. Intermittent claudication is the cramp-like pain in your legs when you walk and is caused by insufficient blood supply in your legs. After 12 weeks, as compared to placebo, Pletal mg b. However, pletal, caution is advised in patients receiving both cilostazol and any anticoagulant agent, and frequent monitoring is required to reduce the possibility of bleeding. In case of retinal bleeding administration of cilostazol should be stopped. Very common Common Uncommon Rare Very rare. Pletal may do the same to other medicines. The stomach should be emptied by induced vomiting or gastric lavage, as appropriate. Qualitative and quantitative composition 3. Healthcare professionals are asked to report any suspected adverse reactions. Cilostazol 50 mg-TEV, white, rectangular. There are no special dosage requirements for the elderly. Cilostazol also inhibits smooth muscle cell proliferation in rat and human smooth muscle cells in vitroand inhibits the platelet release reaction of platelet-derived growth factor and PF-4 in human platelets. Based on these data, the recommended dose of cilostazol is 50 mg bid in the presence of omeprazole. If you experience easy bruising or bleeding, stop taking Pletal and tell your doctor. Maize starch, microcrystalline cellulose, carmellose calcium, hypromellose and magnesium stearate. At lower dose levels, retardations of ossification were observed. Exposure in late pregnancy resulted in an increased frequency of stillbirths and lower offspring weights.

Pletal

Patients should be warned to report any episode of bleeding or easy bruising whilst on therapy. If you are pregnant, pletal, think you may be pregnant or if you are breast-feeding ask your doctor or pharmacist for advice before taking any medicine. Lactation The transfer of cilostazol to breast milk has been reported in animal studies. Palpitation, tachycardia, angina pectoris, arrhythmia, ventricular extrasystoles Myocardial infarction, atrial fibrillation, congestive heart failure, supraventricular tachycardia, ventricular tachycardia, syncope. This dose does not need to be changed for elderly people. Stop taking Pletal and contact a doctor or go to the nearest hospital immediately. Refer also to section 4. Respiratory, thoracic and mediastinal disorders. No effect on fertility was observed in rats or in non-human primates. Studies in animals and in man in vivo and ex vivo have shown that cilostazol causes reversible inhibition of platelet aggregation. To bookmark a medicine you must sign up and log in. All healthy subjects in the study had a prolongation of bleeding time on clopidogrel alone and concomitant administration with cilostazol did not result in a significant additional effect on bleeding time. Administration of a single dose of mg cilostazol with ml grapefruit juice an inhibitor of intestinal CYP3A4 did not have a notable effect on the pharmacokinetics of cilostazol. One tablet contains 50 mg or mg cilostazol. Cilostazol should be taken pletal minutes before breakfast and the evening meal. Take special care with Pletal Before taking Pletal make sure your doctor knows: Intermittent claudication is the cramp-like pain in your legs when you walk and is caused by insufficient blood supply in your legs. Ask your pharmacist how to dispose of medicines no longer required. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided.

The following side effects have pletal reported for Pletal, pletal. The risk of intraocular bleeding may be higher in patients with diabetes. You can help by reporting any side effects you may get. Always take your pletal with a drink of water. The pletal dosage of cilostazol is mg twice a day. This information is for educational purposes only, and not meant to provide medical advice, pletal, treatment, or pletal. No dosage adjustment is necessary in patients with mild hepatic disease. Drug information contained herein may be time sensitive. If you get any side effects, talk to your doctor or pharmacist. The stomach should be emptied by induced vomiting or gastric lavage, as appropriate. Oral Anticoagulants like warfarin. Some benefits of taking Pletal may be felt within weeks of treatment. Therefore, drugs inhibiting CYP3A4 e. This medicinal product is subject to additional monitoring. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. Stop taking Pletal and contact a doctor or go to the nearest hospital immediately. Effects on circulating plasma lipids have been examined in patients taking Pletal. Pletal is indicated for the improvement of the maximal and pain-free walking distances in patients with intermittent claudication, who do not have rest pain and who do not have evidence of peripheral tissue necrosis peripheral arterial disease Fontaine stage II. Other potential interactions Caution is needed when co-administering cilostazol with any other agent which has the pletal to reduce blood pressure due to the possibility that there may be an additive hypotensive effect with a reflex tachycardia. Cilostazol 50 mg-APO, white, round.

Cilostazol should be taken pltal minutes before breakfast pletql the evening meal. The following side effects have been reported during the use of Pletal but it pletal not known how frequently they may occur: This dose does not need to be changed for elderly people. Enter medicine name or company Start typing to retrieve search pletal. This site uses cookies. However, the AUC for cilostazol and its metabolites increase approximately proportionately with dose. Pletall you start taking Pletal, please tell your doctor if pletal are taking: Pletal mg tablets 2. This information is for educational pletal only, and not meant to provide medical advice, treatment, or p,etal. Pletal is not suitable for children, pletal. Animal studies have shown cilostazol to have pletal effects and this has been demonstrated in small studies in man where pletal blood flow was measured by strain gauge plethysmography. An increased frequency of retardation of ossification of the sternum was observed in rabbits. Caution is advised plettal case of co-administration with statins metabolised by CYP3A4, for example simvastatin, atorvastatin and lovastatin. Find out more here. See the end of section 4 for how to report side effects. This will allow quick identification of new safety information. Cilostazol reversibly impaired fertility of female mice but not in other animal species see section 5. Following multiple doses of cilostazol mg twice daily in patients with peripheral vascular disease, pletal state is achieved within 4 days.

Legal Category

Remember to always consult your physician or health care provider before starting, stopping, or ppetal a treatment or health care regimen. Patients who may be at increased risk for serious cardiac adverse events as a result of increased heart rate, e. John's wort on cilostazol pharmacokinetics has not been evaluated. A full blood count should be performed if infection is suspected or there is any other clinical evidence plwtal blood dyscrasia. Caution is advised when cilostazol is co-administered with CYP3A4 substrates with a narrow therapeutic index pleyal. Enter medicine name or company Start typing to retrieve search suggestions. Based on these data, the recommended dose of cilostazol is 50 mg bid in the presence of ketoconazole and similar agents e. In case of retinal bleeding administration of cilostazol should be stopped. How to store Pletal 6. Pletao to cilostazol's platelet aggregation inhibitory effect it is possible that an increased bleeding risk occurs in combination with surgery including minor invasive measurements like tooth extraction. Posology The recommended dosage of cilostazol is mg twice a day. Sign Up Log In Cancel. A clinically relevant effect on cilostazol is still possible at higher quantities of grapefruit juice. Pletal 50 mg and mg tablets Package leaflet: Do not pass it on to others.

Pletal mg tablets 2. Qualitative and quantitative composition One tablet contains mg of cilostazol. However, the AUC for cilostazol and its metabolites increase approximately proportionately with dose. In rats dosed during pregnancy, foetal weights were decreased. Pletal is indicated for the improvement of the maximal and pain-free walking distances in patients with intermittent claudication, who do not have rest pain and who do not have evidence of peripheral tissue necrosis peripheral arterial disease Fontaine stage II. Cilostazol 50 mg-AND, white, round,. If a patient is to undergo elective surgery and antiplatelet effect is not necessary, cilostazol should be stopped 5 days prior to surgery. The dehydro metabolite, which has times the potency of cilostazol in inhibiting platelet aggregation, appears to be formed primarily via CYP3A4. Last updated on eMC: In a clinical study in healthy subjects, cilostazol given mg b. Mutagenicity studies were negative in bacterial gene mutation, bacterial DNA repair, mammalian cell gene mutation and mouse in vivo bone marrow chromosomal aberrations. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. In addition to reporting episodes of bleeding and easy bruising, patients should be warned to promptly report any other signs which might also suggest the early development of blood dyscrasia such as pyrexia and sore throat. Following multiple doses of cilostazol mg twice daily in patients with peripheral vascular disease, steady state is achieved within 4 days. However, your doctor may prescribe a lower dose if you are taking other medicines which may interfere with the effect of Pletal. Before you take Pletal 3. The suitability of treatment with cilostazol should be carefully considered alongside other treatment options such as revascularisation. Renal failure, renal impairment Haematuria, pollakiuria. Sign Up Log In Cancel. The stomach should be emptied by induced vomiting or gastric lavage, as appropriate. This includes any possible side effects not listed in this leaflet. Eye haemorrhage, epistaxis, gastrointestinal haemorrhage, haemorrhage unspecified, orthostatic hypotension Hot flushes, hypertension, hypotension, cerebral haemorrhage, pulmonary haemorrhage, muscle haemorrhage, respiratory tract haemorrhage, subcutaneous haemorrhage. A randomized, double-blind, placebo-controlled Phase IV study was conducted to assess the long-term effects of cilostazol, with focus on mortality and safety. This information is intended for use by health professionals. The stomach should be emptied by induced vomiting or gastric lavage, as appropriate. Cilostazol 50 mg-AND, white, round. It may harm them, even if their symptoms are the same as yours. Based on these data, the recommended dose of cilostazol is 50 mg bid in the presence of omeprazole. The usual dose is two 50 mg tablets twice pletal day morning and evening. Find out more here. Cilostazol per se pletal carry an increased risk of pletql and plwtal risk may be potentiated by co-administration with any other agent with such potential. Qualitative and quantitative composition 3.

Common Uncommon Interstitial pneumonia. Sign Up Log In Cancel. Possible side effects 5. If you are taking such medicines with Pletal your doctor may perform some routine blood tests. If you stop taking Pletal If you stop taking Pletal the pain in your legs may come back or get worse. If you have taken more tablets than your prescribed dose, contact your doctor or your local hospital immediately. Cilostazol 50 mg-APO, white, round,. It has several actions which include widening of some blood vessels and reducing the clotting activity clumping of some blood cells called platelets inside your vessels. By continuing to browse the site you are agreeing to our policy on the use of cookies. The usual dose is two 50 mg tablets twice a day morning and evening. Pletal may do the same to other medicines. This medicinal product does not require any special storage conditions. If you are pregnant, think you may be pregnant or if you are breast-feeding ask your doctor or pharmacist for advice before taking any medicine. In such cases, a cilostazol dosage of 50 mg twice daily is recommended see section 4. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The elderly There are no special dosage requirements for the elderly. You can also report side effects directly via the Yellow Card Scheme at: Pregnancy There are no adequate data in the use of cilostazol in pregnant women. Caution is advised when co-administering cilostazol with any drug that inhibits platelet aggregation. This will allow quick identification pletal new safety information. Cilostazol per se may carry an poetal risk of bleeding and this risk may be potentiated by co-administration with any other agent pletxl such potential. If you have any further questions, please ask your doctor or your pharmacist. Every effort has been made to ensure that pletal information provided by on this page pletal accurate, up-to-date, and complete, but no guarantee is made to that effect. It is written for patients and gives information about taking or using a medicine.