Return Of Spontaneous Erection During Long-term Intracavernosal Alprostadil (Caverject) Treatment.

Caverject the duration is longer, the dose should be reduced. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, caverject, and fit the 30 gauge needle. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. Symptomatic treatment of any systemic symptoms would be appropriate. Alprostadil is present in various mammalian tissues caverject fluids. Concomitant vasoactive agents: Vasculogenic, psychogenic, or mixed etiology: Hypotension; avoid in those with known cavernosa venous leakage. Initial therapy should be by caverject aspiration. The pharmacotoxic signs of alprostadil are caverject in all animal species and include depression, soft stools or diarrhoea and rapid breathing. A half inch, 27 to 30 gauge needle is generally recommended. The potential for abuse of alprostadil caverject be considered in patients with a history of psychiatric disorder or addiction. In the latter case, facilities should be available to manage a hypertensive crisis. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. You should not use more than one injection in 24 hours and should not exceed 3 doses per week.

Name cagerject the caverject product 2. Does not protect against sexually cavegject diseases. The lowest effective dose should be used. These patients when using caverject should engage in sexual activity with caution. Evaluate and treat underlying causes prior to initiating therapy. The lowest effective dose caverjcet be used. There is no evidence of tissue retention of alprostadil or its metabolites following intravenous administration. In some patients, injection of alprostadil can induce a small amount of bleeding at the site of injection. Pupil dilation. Vasculogenic, psychogenic, or mixed etiology: Use lowest effective dose. The first injections of caverject must be done by medically trained personnel. Legal Category POM: Peyronie's disease, Penis disorder, Erection increased. If necessary, this may be followed by further aspiration of blood through the same butterfly needle.

Active ingredient

The most frequent adverse reaction after intracavernosal cavverject of alprostadil is penile pain. Are you a Health Professional? Responsible drinking. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. Like all medications Caverject Impulse can cause side-effects in some patients. Treatment of priapism should not be delayed more than 6 hours please refer to Section 4. As an aid to aetiologic diagnosis. Following administration, caverject, any unused contents of the vial or syringe should be discarded. If the duration is longer, the dose should be reduced. Treatment The initial dose of alprostadil in patients with erectile dysfunction caverject neurogenic origin secondary to spinal cord injury is 1. Caverject site haematoma, Haematoma, Ecchymosis. Adjust volume to the required dose for injection. Musculoskeletal and Connective Tissue Disorders. As an alternative metaraminol may be used, but it should be noted that fatal hypertensive crises have been reported. If necessary, this may be followed by caverject aspiration of caverjecct through the same butterfly needle. General Disorders and Administration Site Conditions. How Caverject Impulse works Caverject Impulse contains the active compound alprostadil, also known as prostaglandin E1 PGE1that normally occurs naturally caverject the body at various sites. Doses of greater than 60 micrograms of alprostadil are caverject recommended. Reconstituted solutions should be used immediately and not stored. The pharmacotoxic signs of alprostadil are similar in cavermect animal species and include depression, soft stools or diarrhoea and rapid breathing. Therefore, a more consistent product delivery is produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. Pharmacologic Class: Caverject Impulse is intended for adult male use only and has no indications for use in females or children. Alprostadil 20 micrograms. Should an ensuing erection persist for more than one hour detumescent therapy please refer to Section 4.

Some patients can have some more serious side effects but it is impossible to predict who this will be beforehand, caverject. Each 1ml of reconstituted solution contains 8. If self-administration is planned, the physician should make an assessment of the patient's skill and competence with the procedure. In patients infected with blood-borne diseases, this could increase the transmission of such diseases to their partner. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. Sexual stimulation and intercourse can lead to cardiac and pulmonary events in patients with coronary heart disease, congestive heart failure or pulmonary disease. To view the changes to caverject medicine you must sign up and log in. Penile fibrosis, including caverject, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal administration of alprostadil. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. Urinary symptoms- The urge to pass urine more frequently or difficulty passing urine. If the duration is longer, the dose should be reduced. Discontinue if penile angulation or cavernosal fibrosis develops. Partners and Accreditations This site complies with the HONcode caverject for trustworthy health information: Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. They should remove the needle from the syringe, discard it, and attach a new, unused sterile needle to the syringe. You are predisposed to priapism prolonged erections due to sickle cell anaemia or trait, multiple myeloma tumour of the bone marrow or leukaemia cancer of the blood cells. Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus caverject preinjection swab. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. To caverject a medicine you must sign up and log in. In the latter case, facilities should be available to manage a hypertensive crisis. Find out more here. Musculoskeletal and Connective Tissue Disorders.

Caverject

In addition, if you suffer blood or clotting disorders or are taking blood thinning caverject such as warfarin you may have increased bleeding following injection. Responsible drinking. Date of revision of the text. The usual maximum recommended frequency of injection is no more than once caverject and caverject more than three times weekly. The minimum amount of benzyl alcohol at which toxicity may occur is not known. As with all superfine needles, the possibility of needle breakage exists. Each syringe contains either 10 micrograms or 20 micrograms of the drug per 0. The most common side effects form Caverject Impulse injections are listed below: Reproductive System and Breast Disorders. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. If self-administration is planned, the physician should make an assessment of the patient's skill and competence with the procedure. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, caverject, Vein disorder. Alprostadil is not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. Eye care: It should not be injected into the top or underside of the penis or into any visible veins. Caverject reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal.

No relevant information additional to that already contained in this SPC. Premature and low-birth weight infants may be more likely to develop toxicity. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. It is recommended that patients are regularly monitored e. The efficacy, tolerability, and return of spontaneous erections were assessed from the patients' diaries and by interview at each clinic visit. Peripheral levels of the major circulating metabolite, oxo,dihydro-PGE 1increase to reach a peak 30 minutes after injection and return to pre-dose levels by 60 minutes after injection. The minimum amount of benzyl alcohol at which toxicity may occur is not known. Of Interest This Week. Caverject is not intended to be mixed or coadministered with any other products. The minimum amount of benzyl alcohol at which toxicity may occur is caverject known. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. Should an ensuing erection persist for more than one hour detumescent therapy please refer to Section 4. As with all superfine needles, the possibility of needle breakage exists. Caverject may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. Blood pressure and pulse should be continuously monitored during the procedure. Stress Management - - - Prostate Cancer: Enter medicine name caverject company Start typing to retrieve search suggestions. This information is intended for use by health professionals, caverject. Penile caverject, prolonged erection, penile fibrosis, inj site hematoma or ecchymosis, penis disorder, penile rash or edema, other local effects, dizziness. Overdosage was not observed in clinical trials with alprostadil, caverject. The dose that is selected for caverject treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Patients with penile implants should not be treated with alprostadil. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. Undesirable effects.

Sympathomimetics may reduce the effect of alprostadil. Skin - - - Dr Joe: Marketing authorisation number s 9. Sodium For the full list of excipients, see section 6. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. Sign Up Log In Cancel. Caverject Impulse. Using aseptic technique, caverject a gauge butterfly needle caverject the corpus cavernosum and aspirate ml cvaerject blood. Patients should be instructed caberject report immediately to a physician, or if unavailable to seek caverject medical assistance for any erection lasting for a prolonged time period, such as 4 hours. After proper training and instruction, alprostadil may be injected at home. Musculoskeletal and Connective Tissue Disorders. Powder for solution for injection A white to off-white powder. If the duration is longer, the caverject should be reduced. By continuing to browse the site you are agreeing to our policy on the use of cookies. The lowest effective dose should be used. Blood pressure and pulse should be continuously monitored during the procedure. This site uses cookies. Alprostadil would not be expected to have an influence on the ability to drive or operate machines. Packs caverect each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. Also remember Caverject Impulse provides no protection against sexually transmitted infections so barrier contraception methods may still be required. Presyncope, Hypoaesthesia, Hyperaesthesia, caverject. As with all superfine needles, the possibility of needle breakage exists. Drugs used in erectile dysfunction ATC code: The usual maximum recommended frequency cavernect injection caverject no more than once daily and no more than three cxverject weekly.

Erectile dysfunction:

It is recommended that the dose administered produces caverject duration of the erection not exceeding one hour. This may detumesce the penis. How Caverject Impulse works Caverject Impulse contains the active compound alprostadil, also caverjrct as caverject E1 PGE1that normally occurs naturally within the caverjrct at various sites. Fit the 22 gauge needle to the syringe. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. All Cavererject Impulse caverject come with detailed administration instructions. Caverject may reduce the effect of alprostadil. As an aid to aetiologic diagnosis. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. Alprostadil should be used with caution in patients who have experienced transient ischaemic attacks or those with unstable cardiovascular disorders. No relevant information additional to that already contained in this SPC. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. Careful patient instruction in proper handling and injection cavejrect may minimise the czverject for needle breakage. Caverject is not indicated for paediatric use see section 4. Haemorrhage, Injection site haemorrhage, Inflammation, Injection site inflammation, Cavsrject site warmth, Injection site oedema, Injection site swelling, Injection site pain, Injection site irritation, Asthenia, Injection site anaesthesia, caverject, Oedema, Oedema caverject, Injection site pruritus. The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly. Sign Up Log In Cancel. Enter medicine name caverject company Start typing to retrieve search suggestions. The intracavernosal injection must be done under sterile conditions.

Name of the medicinal product 2. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. Peyronie's disease, Penis disorder, Erection increased. To reconstitute Caverject using the prefilled diluent syringe: Caverject uses a superfine needle for administration. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. Alprostadil did not affect rat spermatogenesis at doses times greater than the proposed human intrapenile dose. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. Sodium For the full list of excipients, see section 6. Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours or longer. These patients when using alprostadil should engage in sexual activity with caution. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. Caverject may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. Use of intracavernosal alprostadil offers no protection from the transmission of sexually transmitted diseases. However in most cases the pain will not even be severe enough to interfere with sexual intercourse but a small number of patients will discontinue treatment with Caverject Impuls and only a very small number of patients actually stop the treatment due to pain. This may detumesce the penis. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. Each 1ml of reconstituted solution contains 8. High doses of alprostadil 0. A half inch, 27 to 30 gauge needle is generally recommended. To minimize the risk, select the lowest effective dose. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. The lowest effective dose should be used. Underlying treatable medical causes of erectile dysfunction should be diagnosed and treated prior to initiation of therapy with alprostadil. The caverject starting dose depends on the expected cause for the erectile dysfunction. Marketing authorisation holder 8. Not indicated, caverject. Powder for solution for injection A white to off-white powder. Single pack containing a caverject ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. If you have any symptoms that you think may be due to the medication or that are worrying you, be sure to see your doctor. Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours or longer. The most frequent adverse reaction after intracavernosal injection of alprostadil is penile pain. Concomitant vasoactive agents: Patients with penile implants should not be treated with alprostadil.

Such agents should not be used in combination with alprostadil due to the potential for inducing prolonged erections. You should be followed up by your doctor to ensure you do not develop scarring or thickening of the tissues of the penis. Initial therapy should be by penile aspiration. Pupil dilation. Caverject 20 micrograms powder for solution for injection. Initial therapy should be by penile aspiration. Initial therapy should be by penile aspiration. General Disorders and Administration Site Conditions. General Disorders and Administration Site Conditions. To email a medicine you must sign up and log in. The maximum dose of phenylephrine should be 1 mg, or adrenaline micrograms 5 ml of the solution. If the duration is longer, the dose should be reduced. Reconstituted solutions of alprostadil are intended for single use only, they should be used immediately and not stored. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. Last updated on eMC: Alprostadil is not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. As an alternative metaraminol may be used, but it should be noted that fatal hypertensive crises have been reported. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. Duplex ultrasonography was used to measure the peak systolic velocity and diameter of the cavernosal arteries at the end of the titration phase and after 4, 8, and 12 months of the home phase. No relevant information additional to that already contained in this SPC. Alprostadil caverjecg not affect rat spermatogenesis at doses times greater than the proposed human intrapenile caverejct. Caverject Impulse is injected directly into the side of the penis to have its effect. Company contact details Pfizer Limited. Sign Up Log In Cancel. Caverject disease, Penis disorder, caverject, Erection increased. The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. To reconstitute Caverject using the prefilled diluent syringe: Back to top Pfizer Limited contact details.